However, when a urine culture is checked, it returns a negative for infection result. One of the possible reasons for these women is that they have a chronic condition called Interstitial cystitis, otherwise known as Bladder Pain Syndrome.

What is Interstitial Cystitis (IC) or Bladder Pain Syndrome (BPS)?

Rather than an infection, IC/BPS is a chronic inflammatory condition. It is thought to be due to the bladder being deficient in its normal “slime layer”, a mucous-like coating that keeps the bladder from being irritated by urine. IC/BPS is like having a diaper-rash inside the bladder. Because the bladder is irritated, IC/BPS symptoms can mimic those of a bladder infection.

Why does IC/BPS occur?

The exact reason IC/BPS occurs is unknown. It is more common in women, and it can also be associated with other chronic conditions such as endometriosis and irritable bowel syndrome. Flare-ups can be triggered by eating certain foods, stress, sex, or during a woman’s period.

What foods cause IC/BPS flare-ups?

The Interstitial Cystitis Association has a more comprehensive list of foods, and instructions on following an elimination diet to identify potential trigger foods. But in general, inflammatory foods to avoid include: Coffee, tea, soda, chocolate (especially dark chocolate), alcohol, citrus juices, cranberry juice, artificial sweeteners, smoked or cured meats, hot peppers, and spicy foods.

How is IC/BPS diagnosed?

To diagnose IC/BPS, your doctor will likely take a history and possibly ask you to fill out a symptom questionnaire. Also, they will probably perform a physical exam, a urinalysis, and urine culture. Further tests could include a procedure called a bladder instillation, or another procedure called a cystoscopy.

What is a bladder instillation?

A bladder instillation is a procedure usually performed in the doctor’s office where a small catheter is placed into the bladder. After the bladder is empty, the doctor infuses a medication into the bladder, and the catheter is removed.

The instillation can be performed once, or weekly for several weeks. The medications used can be either a solution of lidocaine (a local anesthetic) and heparin (which is thought to act by simulating the bladder’s mucous coating), or another medication called DMSO (di-methylsulfoxide) which is thought to decrease inflammation in the bladder.

If the patient develops symptom relief with these treatments, the diagnosis of IC/BPS can be presumed.

What is a cystoscopy?

A cystoscopy is a procedure where a long, thin instrument with a cystoscope lens is placed through the urethra into the bladder. Water is used to fill the bladder, and the doctor looks through the lens to visualize the inside.

Cystoscopy can be done in an office setting using a local anesthetic gel, in a surgical center or a hospital setting under general anesthesia. My personal preference to diagnose IC/BPS is in an ambulatory surgery center or hospital with the patient under anesthesia.

This surgical site selection allows me to better evaluate the lining of the bladder. During the cystoscopy, I will fill the bladder to stretch it. This distension would be uncomfortable if the patient were awake. The overfilled bladder allows the surgeon to see the presence of small areas of bleeding, called glomerulations. These are present in a patient with IC/BPS, whereas a normal bladder will not have them.

By demonstrating the presence of glomerulations, I am able to confirm the diagnosis of IC/BPS. Additionally, distending the bladder often provides symptom relief to the patient. Finally, for patients who have had long-standing IC/BPS, they may develop Hunner’s Ulcers inside the bladder. If these are seen during cystoscopy, they can be injected with steroids to provide symptom relief.

Are there medications to treat IC/BPS?

There are several medications to treat IC/BPS. There is one medication which is approved to treat IC/BPS. It is called pentosan sulfate; the trade name is Elmiron. There are several medications that have been used off-label to help manage IC/BPS symptoms. These include:

1. Anti-histamines such as hydroxyzine
2. Tri-cyclic anti-depressants such as amitriptyline
3. Neuro-modulators such as gabapentin.

What if I don’t have IC/BPS?

The symptoms of IC/BPS can also be caused by several other conditions. cystitis (bladder infection), overactive bladder (OAB), and less commonly bladder cancer can all have similar symptoms. That is why it is important to see a physician who is experienced in diagnosing and treating these conditions if your symptoms continue despite routine treatments.

These other conditions are treatable but may require other tests and treatments.

Where can I get more information?

Your doctor can give you more information and help you with the diagnosis and treatment of your symptoms. In addition, the following websites provide valuable resources.

• American Urogynecologic Association
• Interstitial Cystitis Association
• Interstitial Cystitis Network

This article was contributed by MacArthur Medical Center’s Dr. Kevin O’Neil and originally published on Medika Life

The post Why Frequent UTI’s Might Be Interstitial Cystitis or Bladder Pain Syndrome appeared first on Medika Life.

The inner lining of the urinary bladder is a mucous membrane of transitional epithelium that is continuous with that in the ureters. When the bladder is empty, the mucosa has numerous folds called rugae. The rugae and transitional epithelium allow the bladder to expand as it fills.

The second layer in the walls is the submucosa, which supports the mucous membrane. It is composed of connective tissue with elastic fibers.

The next layer is the muscularis, which is composed of smooth muscle. The smooth muscle fibers are interwoven in all directions and, collectively, these are called the detrusor muscle. Contraction of this muscle expels urine from the bladder. On the superior surface, the outer layer of the bladder wall is parietal peritoneum. In all other regions, the outer layer is fibrous connective tissue.

There is a triangular area, called the trigone, formed by three openings in the floor of the urinary bladder. Two of the openings are from the ureters and form the base of the trigone. Small flaps of mucosa cover these openings and act as valves that allow urine to enter the bladder but prevent it from backing up from the bladder into the ureters. The third opening, at the apex of the trigone, is the opening into the urethra. A band of the detrusor muscle encircles this opening to form the internal urethral sphincter.

Shape of the Bladder

The appearance of the bladder varies depending on the amount of urine stored. When full, it exhibits an oval shape, and when empty it is flattened by the overlying bowel.

The external features of the bladder are:

• Apex – located superiorly, pointing towards the pubic symphysis. It is connected to the umbilicus by the median umbilical ligament (a remnant of the urachus).
• Body – main part of the bladder, located between the apex and the fundus
• Fundus (or base) – located posteriorly. It is triangular-shaped, with the tip of the triangle pointing backwards.
• Neck – formed by the convergence of the fundus and the two inferolateral surfaces. It is continuous with the urethra.

Urine enters the bladder through the left and right ureters, and exits via the urethra. Internally, these orifices are marked by the trigone – a triangular area located within the fundus.

In contrast to the rest of the internal bladder, the trigone has smooth walls (this is explained by the different embryological origin: the trigone is developed by the integration of two mesonephric ducts at the base of the bladder).

Musculature

The musculature of the bladder plays a key role in the storage and emptying of urine.

In order to contract during micturition, the bladder wall contains specialised smooth muscle – known as detrusor muscle. Its fibres are orientated in multiple directions, thus retaining structural integrity when stretched. It receives innervation from both the sympathetic and parasympathetic nervous systems.

The fibers of the detrusor muscle often become hypertrophic (presenting as prominent trabeculae) in order to compensate for increased workload of the bladder emptying. This is very common in conditions that obstruct the urine outflow such as benign prostatic hyperplasia.

There are also two muscular sphincters located in the urethra:

• Internal urethral sphincter:
  • Male – consists of circular smooth fibres, which are under autonomic control. It is thought to prevent seminal regurgitation during ejaculation.
  • Females – thought to be a functional sphincter (i.e. no sphincteric muscle present). It is formed by the anatomy of the bladder neck and proximal urethra.
• External urethral sphincter – has the same structure in both sexes. It is skeletal muscle, and under voluntary control. However, in males the external sphincteric mechanism is more complex, as it correlates with fibers of the rectourethralis muscle and the levator ani muscle.

The Bladder Stretch Reflex

The bladder stretch reflex is a primitive spinal reflex, in which micturition is stimulated in response to stretch of the bladder wall. It is analogous to a muscle spinal reflex, such as the patella reflex.

During toilet training in infants, this spinal reflex is overridden by the higher centres of the brain, to give voluntary control over micturition.

The reflex arc:

• Bladder fills with urine, and the bladder walls stretch. Sensory nerves detect stretch and transmit this information to the spinal cord.
• Interneurons within the spinal cord relay the signal to the parasympathetic efferents (the pelvic nerve).
• The pelvic nerve acts to contract the detrusor muscle, and stimulate micturition.

Although it is non-functional post childhood, the bladder stretch reflex needs to be considered in spinal injuries (where the descending inhibition cannot reach the bladder), and in neurodegenerative diseases (where the brain is unable to generate inhibition).

The post The Urinary Bladder appeared first on Medika Life.

Healthy kidneys filter about a half cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. Your bladder stores urine. Your kidneys, ureters, and bladder are part of your urinary tract.

Each of your kidneys is made up of about a million filtering units called nephrons. Each nephron includes a filter, called the glomerulus, and a tubule. The nephrons work through a two-step process: the glomerulus filters your blood, and the tubule returns needed substances to your blood and removes wastes.

Kidney Structure

The kidneys are encased in complex layers of fascia and fat. They are arranged as follows (deep to superficial):

• Renal capsule – tough fibrous capsule.
• Perirenal fat – collection of extraperitoneal fat.
• Renal fascia (also known as Gerota’s fascia or perirenal fascia) – encloses the kidneys and the suprarenal glands.
• Pararenal fat – mainly located on the posterolateral aspect of the kidney.

Internally, the kidneys have an intricate and unique structure. The renal parenchyma can be divided into two main areas – the outer cortex and inner medulla. The cortex extends into the medulla, dividing it into triangular shapes – these are known as renal pyramids.

The apex of a renal pyramid is called a renal papilla. Each renal papilla is associated with a structure known as the minor calyx, which collects urine from the pyramids. Several minor calices merge to form a major calyx. Urine passes through the major calices into the renal pelvis, a flattened and funnel-shaped structure. From the renal pelvis, urine drains into the ureter, which transports it to the bladder for storage.

The medial margin of each kidney is marked by a deep fissure, known as the renal hilum. This acts as a gateway to the kidney – normally the renal vessels and ureter enter/exit the kidney via this structure.

Arterial Supply

The kidneys are supplied with blood via the renal arteries, which arise directly from the abdominal aorta, immediately distal to the origin of the superior mesenteric artery.  Due to the anatomical position of the abdominal aorta (slightly to the left of the midline), the right renal artery is longer, and crosses the vena cava posteriorly.

The renal artery enters the kidney via the renal hilum. At the hilum level, the renal artery forms an anterior and a posterior division, which carry 75% and 25% of the blood supply to the kidney, respectively. Five segmental arteries originate from these two divisions.

The avascular plane of the kidney (line of Brodel) is an imaginary line along the lateral and slightly posterior border of the kidney, which delineates the segments of the kidney supplied by the anterior and posterior divisions. It is an important access route for both open and endoscopic surgical access of the kidney, as it minimizes the risk of damage to major arterial branches.

The segmental branches of the renal undergo further divisions to supply the renal parenchyma:

• Each segmental artery divides to form interlobar arteries. They are situated either side every renal pyramid.
• These interlobar arteries undergo further division to form the arcuate arteries.
• At 90 degrees to the arcuate arteries, the interlobular arteries arise.
• The interlobular arteries pass through the cortex, dividing one last time to form afferent arterioles.
• The afferent arterioles form a capillary network, the glomerulus, where filtration takes place. The capillaries come together to form the efferent arterioles.

In the outer two-thirds of the renal cortex, the efferent arterioles form what is a known as a peritubular network, supplying the nephron tubules with oxygen and nutrients. The inner third of the cortex and the medulla are supplied by long, straight arteries called vasa recta.

Venous Drainage

The kidneys are drained of venous blood by the left and right renal veins. They leave the renal hilum anteriorly to the renal arteries, and empty directly into the inferior vena cava.

As the vena cava lies slightly to the right, the left renal vein is longer, and travels anteriorly to the abdominal aorta below the origin of the superior mesenteric artery. The right renal artery lies posterior to the inferior vena cava.

Lymphatics

Lymph from the kidney drains into the lateral aortic (or para-aortic) lymph nodes, which are located at the origin of the renal arteries.

The post The Kidneys appeared first on Medika Life.

Male Urethra

The male urethra is approximately 15-20cm long. In addition to urine, the male urethra transports semen – a fluid containing spermatozoa and sex gland secretions.

According to the latest classification, the male urethra can be divided anatomically into three parts (proximal to distal):

• Prostatic urethra:
  • Begins as a continuation of the bladder neck and passes through the prostate gland.
  • Receives the ejaculatory ducts (containing spermatozoa from the testes and seminal fluid from the seminal vesicle glands) and the prostatic ducts (containing alkaline fluid).
  • It is the widest and most dilatable portion of the urethra.
• Membranous urethra:
  • Passes through the pelvic floor and the deep perineal pouch.
  • Surrounded by the external urethral sphincter – which provides voluntary control of micturition.
  • It is the narrowest and least dilatable portion of the urethra.
• Penile (bulbous) urethra:
  • Passes through the bulb and corpus spongiosum of the penis, ending at the external urethral orifice (the meatus).
  • Receives the bulbourethral glands proximally.
  • In the glans (head) of the penis, the urethra dilates to form the navicular fossa.

Female Urethra

In females, the urethra is relatively short (approximately 4cm). It begins at the neck of the bladder, and passes inferiorly through the perineal membrane and muscular pelvic floor. The urethra opens directly onto the perineum, in an area between the labia minora, known as the vestibule.

Within the vestibule, the urethral orifice is located anteriorly to the vaginal opening, and 2-3cm posteriorly to the clitoris. The distal end of the urethra is marked by the presence of two mucous glands that lie either side of the urethra – Skene’s glands. They are homologous to the male prostate.

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