She looked at options like uterine myomectomy and uterine fibroid embolization, but she wanted kids one day. She feared the potential impact on her future fertility. She searched for an effective medication to treat her fibroids and reduce her heavy menstrual bleeding. She wanted to get her life back. 

For many years, women with fibroids have sought out menstrual cycle control options beyond oral contraceptives, Depo-Provera injections, and Progesterone IUDs. In May 2020, the U.S. Food and Drug Administration approved Oriahnn™ for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.

What is Oriahnn™?

Oriahnn™ is the only FDA-approved oral medication designed to improve and lighten heavy periods caused by uterine fibroids. Fibroids, also called leiomyomas, are benign uterine tumors that grow in the uterus. Up to 80% of women will develop one or more uterine fibroids during their lifetime. 

Oriahnn™ is a combination product containing elagolix, estradiol, and a type of progesterone called norethindrone acetate. Elagolix is a gonadotropin-releasing hormone antagonist. This term means it suppresses the ovarian sex hormones estrogen and progesterone, both of which stimulate fibroid growth.

The addition of estradiol and norethindrone acetate adds back some of the female hormones to prevent side effects and help thin out the endometrial lining. 

Oriahnn™ is approved for use in premenopausal women to reduce the amount of bleeding caused by uterine fibroids.

Why would a woman want to try Oriahnn™?

Many women suffering from the effects of fibroids seek a non-surgical treatment to control heavy periods. Medial options allow her to reduce her symptoms without impacting her future fertility. An effective medication will enable her to keep her options open.

Older medications, such as Depo-Lupron (leuprolide acetate), are administered as an injection. This type of medication is costly, poorly covered by insurance companies, and often triggers menopausal symptoms such as hot flashes. 

Oriahnn™ comes packaged as a daily oral medication giving women the options to avoid surgery, procedure, or a birth control method. This pill is clinically proven to reduce heavy menstrual bleeding due to uterine fibroids within one month of taking it. 

Oriahnn™ is not birth control. Patients using this medication who do not want to get pregnant may want to consider a nonhormonal contraceptive option such as condoms, Phexxy, spermicide, copper IUDs, or a diaphragm. 

Does Oriahnn™ work? 

Oriahnn™ was studied in two 6-month clinical trials used for FDA approval. These studies included 591 premenopausal women aged 26–53 with heavy periods due to sonographically-confirmed uterine fibroids.

The participants measured menstrual blood loss (MBL) for two cycles before starting Oriahnn™ or a placebo. Only those with greater than 80 ml of MBL qualified for the study.

In the first study, 68.5% of patients who received Oriahnn showed a reduction in menstrual bleeding compared to 8.7% of patients who received a placebo. 

In the second study, 76.5% of patients who received Oriahnn showed an improvement in blood loss compared to 10.5% of patients who received a placebo.

Oriahnn™ was proven to lighten heavy periods in 70% of women with a 50% reduction in menstrual blood loss. During the 6-month clinical trials, only three women required surgery for their uterine fibroids.

What side effects for Oriahnn™?  

During the clinical trials, about 10% of patients stopped treatment because of any side effects. Of note,7% of women taking the placebo also stopped treatment due to side effects.

The most common reported side effects were hot flashes, headache, fatigue, and irregular uterine bleeding.

All products containing estrogen and progestin combinations increase the risk of thrombotic or thromboembolic disorders, including pulmonary embolism, deep vein thrombosis, stroke, and myocardial infarction. A doctor must evaluate a patient’s medical history to determine if these medications are an appropriate option. 

Oriahnn™ may increase the risk of bone loss so the FDA approval recommends limited its use to 24 months. 

A new medical option for fibroids

Gynecologists now have a new option to help women with fibroids. Women with fibroids who want to avoid surgery or birth control may want to consider Oriahnn™. 

This novel medication, back up by clinical evidence, gives women more choices to reduce menstrual bleeding caused by fibroids. 

The post Oriahnn; A Drug to Stop Heavy Periods for Women With Fibroids appeared first on Medika Life.

Every woman suffering from the effects of uterine fibroids deserves to know all of her options. Removing fibroids is not always the answer. While Obgyn physicians are comfortable discussing surgical treatment options, many doctors do not discuss all the alternatives.

Uterine fibroid embolization can be an excellent choice for the many women with fibroids who want to avoid surgery and keep their uterus. This minimally invasive alternative effectively treats fibroid with minimal downtime and recovery. 

Uterine fibroids are one of the most common gynecological conditions with many available treatment options. Educating yourself is a key step to allow you and your doctor to make a joint decision together on the best approach.

I want to keep my uterus. What are my options?

What are uterine fibroids?

Uterine fibroids are benign noncancerous tumors affecting women. Fibroids, also called leiomyomas, are groups of cells that form into a ball of muscle in the walls of the uterus. Up to 80% of women will develop one or more uterine fibroids during their lifetime.

Uterine fibroids behave in strange ways. They may grow slowly or quickly, or they may simply stay the same size throughout a woman’s life. Some women will develop more fibroids while others will not.

Many women are unaware they have fibroids, while others suffer unbearable symptoms. Heavy menstrual periods, pelvic pain, cramping, frequent urination, constipation, painful intercourse, and back pain are common complaints. 

Hysterectomy and myomectomy are not your only option to treat fibroids. 

Women with fibroids who want to avoid surgery and keep their uterus need to know about uterine fibroid embolization. UFE is an important option, but your Gynecologist may not mention it. 

What is a uterine fibroid embolization?

Uterine Fibroid Embolization (UFE) is a minimally invasive procedure to shrink or destroy uterine fibroids. Although fibroids are a common gynecologic condition, this procedure is not done by a gynecologist. 

Instead, this safe and highly effective non-surgical treatment is performed by an interventional radiologist.

To perform a UFE, the doctor inserts a small catheter into an artery in the arm or leg. The doctor injects a substance called IV contrast to project the blood supply onto a video screen via X-ray technology. 

The thin, flexible catheter is then advanced to the location of the fibroid. Small particles called polyvinyl alcohol are pushed through the catheter to block the blood flow to the fibroid. 

Starved of their blood supply, the fibroids shrink and die. 

UFE advantages

UFE has several advantages over hysterectomy and myomectomy.  

1. General anesthesia is not required.
2. No surgical incisions are needed. 
3. There is no blood loss. 
4. Treats adenomyosis. 
5. All fibroids may be treated at the same time. 
6. Minimal downtime and recovery. 
7. Can treat a fibroid of any size. 
8. A viable option for those with a medical condition prohibiting major surgery.

Disadvantages of UFE include:

1. Fertility effects. The long term effects on fertility are not completely understood. While some studies show an increase in fertility, others studies show negative effects. UFE is not typically recommended for women who would like to get pregnant in the future. 
2. Fibroids are not removed. While UFE shrinks and treats the tumors, it does not remove them from the body. 
3. Infection. The risk of infection is quite low but there is a possibility of delayed infection during the first postsurgical year. 
4. The potential need for retreatment. 
5. Not recommended for all types of fibroids. 

All procedures have risks

The risks of UFE is low but include:

1. Infection. The infection risk is low but is a serious, potentially life-threatening complication of UFE. In rare cases, hysterectomy is needed to treat an infected uterus. 
2. Premature menopause. 
3. Amenorrhea. Some women experience a loss of menstrual cycles after UFE. 
4. Pelvic pain. Pain and cramping are rare, but in some cases may persist for the first few months after the procedure. 

Why didn’t my Gynecologist mention UFE? 

Not all gynecologists discuss UFE as an option for uterine fibroids. Some doctors are not aware of UFE. Many have had little to no clinical experience with the procedure. Other Obgyns may have had a negative experience with interventional radiology referrals in the past. 

UFE is a highly specialized procedure and some geographic areas may not have access to a local Interventional radiologist. 

In my experience, I have found UFE to be a safe and effective option for women with fibroids. I am not trained to perform the procedure so I had to educate myself on the risks, benefits, and tremendous value UFE offers. 

Our practice refers patients to Dr. Suzanne Slonim at the Fibroid Institute of Dallas.

The post UFE: Treating Uterine Fibroids without Losing Your Uterus appeared first on Medika Life.