America’s AI Action Plan, recently announced by the Trump Administration, aims to achieve U.S. dominance in artificial intelligence but overlooks a key force multiplier: investing in the American people’s human brainpower. From design to deployment, AI systems reflect and rely on the cognitive capacities of the people who build and use them. 

American ingenuity—what Lincoln called ‘the fire of genius’—has long been the engine of our productivity and progress. From the space race to Silicon Valley, it’s not just natural resources or industrial capacity that set the U.S. apart, but the cognitive, creative, and entrepreneurial capacity of our people – our brain capital.

The Administration’s stated aim of “powering a new age of American leadership in science, technology, and global influence” will not be achieved by silicon and data infrastructure alone. It must be accompanied by investments in a different kind of infrastructure – our national brain infrastructure.

Just as AI relies on chips, cloud networks, and compute power, its success ultimately depends on the human intelligence that shapes, governs, and applies it. The World Economic Forum has identified the capabilities most essential in the AI era: analytical thinking, resilience, creativity, empathy, and curiosity. These are not technical upgrades – they are human ones. Failing to build brain infrastructure means our most powerful tools may evolve faster than our capacity to direct them.

Despite enormous advances in neuroscience, the brain remains one of the least understood organs in the human body. We know that brain health and performance is shaped by everything from genetics and inflammation to early life experiences and social connection, but we lack a full understanding of how these factors interact—or how to intervene most effectively across populations. Rising rates of mental and neurological health conditions are eroding America’s cognitive resilience – threatening our nation’s capacity to learn, work, innovate, and lead. Further, we know very little about how AI itself may reshape our ability to do these things.

While the U.S. is slashing strategic investments in science, education and health, other nations are doubling down. China, for example, has dramatically expanded its national brain science agenda—accelerating brain-computer interface trials, funding neuro-AI innovation, and integrating neuroscience into its economic and defense strategies.  If America fails to act, it risks ceding not just scientific leadership, but the very foundation of AI competitiveness.

To compete with China and lead the next era of innovation, the U.S. must go beyond chips and deregulation. As many European nations already are developing, the United States needs a national brain capital strategy – a Human Intelligence “H.I.” Action Plan – that will enable us to fully flourish and lead.

Any strategy to power a new age of American leadership must expand the aperture beyond the technology that aids us – to include us. This involves prioritizing early child development and strong education systems, and embedding neuroscience-informed learning in schools. It also requires us to address the health and social risk factors that hamper cognitive resilience, scale cognitive capacity across the workforce through tools, culture and design, incentivize brain health innovation across sectors, and address rising rates of mental and neurological health conditions that plague Americans at all ages.

There is no doubt that AI holds the promise of augmenting and accelerating human productivity and scientific discoveries. But we must remember this is a collaboration. Investing in AI without equally investing in human capacity, ethics, and well-being risks collapsing the very foundation we aim to build. By nearly every meaningful measure – life expectancy, happiness, living standards, equality, cognitive resilience – Americans are falling behind. Our technological ambition must be matched by a human one.

The bottom line: we cannot build intelligent systems without fueling human intelligence. The countries that win the AI age will be those that invest not only in machines – but in the cognitive, emotional, and creative capacity of their people.

The post The Missing Piece in America’s AI Strategy: Brain Capital appeared first on Medika Life.

I came to Borneo to let the ground fight back.

This morning, outside Kota Kinabalu, Malaysia, my boots slipped on a tangle of wet roots.

The air smelled of earth and rain.

A quiet hum of life surrounded me.

In that awkward, humbling stumble, I felt something rare:

My body woke up.

The Comfort Trap That’s Making Us Weak

In Seattle, I walk sidewalks and treadmills — smooth, safe, and sterile.

For most of human history, humans moved across shifting ground.

Forests. Fields. Hills.

Every step required micro-adjustments.

Your feet, ankles, and hips worked together without your conscious effort.

But today?

Flat concrete. Cushioned shoes. Escalators and elevators.

The result?

• Weak stabilizer muscles in the feet and ankles
• Poor balance and slower reaction times
• A brain that tunes out during your most basic movement

Comfort stole our strength.

What Science Says About Uneven Ground

Clinical studies confirm what my jungle stumble reminded me:

Walking on uneven terrain:

✔️ Activates foot and ankle stabilizers
✔️ Improves proprioception (your body’s sense of position in space)
✔️ Sharpens reaction time
✔️ Reduces fall risk in older adults
✔️ Boosts mood and cognitive performance

A 2021 study found that older adults walking on rough paths improved their gait stability by 22%.

A separate trial revealed that rugged walking improved working memory and decision-making speed.

In other words: Your steps train your brain.

→ Your feet aren’t the only part of your body that’s asleep. Want to wake up your mind, too?

Join the 100,000 readers who have enjoyed → 10 Tiny Habits That Make You Healthier, Calmer, and Harder to Kill

Orangutans, Cobras — and the Gift of Paying Attention

I paused beneath the jungle canopy.

An orangutan swung overhead, effortless in its grace.

It stared at me as if to say, “You humans forgot how to move.”

A rustle in the underbrush.

Was it a cobra? A monkey?

Or just the wind reminding me to stay alert?

Either way, I wasn’t scrolling my phone.

You can’t walk distracted when the jungle might bite back.

Uneven ground forces presence.

And in a world addicted to autopilot, presence is a rare medicine.

Rough Terrain Rewires Your Brain for Survival

I used to think walking was the ultimate autopilot activity.

But neuroscience says otherwise.

Rough terrain lights up your prefrontal cortex — the part of your brain that handles attention and planning.

Your cerebellum and sensory nerves work overtime to keep you upright.

This sparks:

• Lower cortisol (stress hormone)
• Improved heart rate variability (a marker of resilience)
• Faster reflexes when life throws you off-balance

One landmark study found these brain benefits last long after the walk ends.

So the next time your foot meets uneven ground, know this:

Your brain is rebuilding itself, one step at a time.

Flat Surfaces Make Life Easy — and Make You Fragile

Modern life has flattened our world.

We walk in shoes that numb the sensation.

On surfaces designed to eliminate surprise.

And then we wonder why our balance fades with age.

Falls are the leading cause of injury-related death in people over 65.

However, the danger begins decades earlier, when our feet stop adapting and our brains stop noticing.

How I Brought This Home

Back in Seattle, I made some simple shifts:

✔️ I walked forest trails instead of smooth streets.
✔️ Hiked on pebble beaches where every step shifted.
✔️ Walked barefoot on grass during morning routines.
✔️ Kept a wobble board under my standing desk.
✔️ Balanced on sidewalk curbs instead of staying in the middle of the path.

Small, daily friction makes your body strong again.

And one more thing — stay safe.

Choose trails appropriate for your skill level, watch your footing, and skip barefoot walking where sharp rocks or hidden hazards could cause injury.

How to Start (No Jungle Required)

Here’s how I coach patients and friends to rebuild strength and balance:

✔️ Choose uneven surfaces: dirt trails, grassy parks, rocky beaches, or mulch paths.
✔️ Go barefoot (when safe): start on grass, packed earth, or soft sand.
✔️ Slow your pace: give your body time to adapt.
✔️ Add balance drills: balance on logs, low curbs, or balance cushions indoors.

You don’t need to overhaul your life.

But you do need to stop walking only on flat, predictable ground.

Adaptation is the Goal — Not Perfection

The real danger isn’t falling.

It’s losing your ability to adapt.

On uneven ground, your body learns to adjust.

Your brain stays alert.

Your nervous system sharpens.

It’s not about avoiding every stumble.

It’s about responding better when you do.

What Happens If You Ignore This?

If you wait until your balance is depleted, regaining it becomes harder.

The loss happens slowly:

• Your stabilizer muscles atrophy.
• Your reaction time slows.
• Your confidence erodes.

But rebuilding is simple.

Step off the pavement.

Find a trail.

Let the ground challenge you again.

Of course, be safe and don’t take unnecessary risks.

Final Thoughts: What the Jungle Taught My Feet

By the end of my hike, my legs were burning, and my boots were caked with mud.

But my mind felt clearer than it had in months.

Maybe this is what we’re wired for:

Not flat streets. Not endless comfort.

But uneven steps that challenge and strengthen us.

Modern life has made our paths smooth.

But with a little intention, we can rebuild what we lost — balance, strength, awareness.

And maybe, in the process, discover something deeper than comfort:

Vitality.

→ Ready to take the first step toward a stronger, sharper you?

Follow me on Medium for science-based habits to help you thrive in a chaotic world.

One more thing — My best-selling ebook: Extending Life and Healthspan

The post The Surprising Health Benefits of Walking on Uneven Ground — And Why You Should Start Today appeared first on Medika Life.

Q&A

Gil Bashe: You called Converge\OIST the “very first gathering.” Why did Okinawa feel like the right birthplace?

Yasushi Yamamoto: Yes, this is the very first gathering, and we named it Converge\OIST because I’m a big fan of ‘OIST’—the context of the birth, this location, these people. It was the right place and people, a great gathering, and a pleasure to meet old friends in such a beautiful, inspiring place.

Gil Bashe: Your career bridges Tokyo boardrooms and Jerusalem start-ups. Where did your obsession with “convergence” begin?

Yasushi Yamamoto: Innovation cannot be done in an isolated form; it should be done in collaboration with various fields. Professionals with beautiful résumés in Tokyo surround me, but many lack a broader vision. They are so good at something particular, yet it’s a pity they’re busy in silos. I saw the lack of collaboration and started my business, raising money from Japanese corporations for Israeli start-ups. That contrast—dinosaurs with big systems but little ‘challenging spirit’ versus entrepreneurs who ‘run and fix’—motivated me to build synergy between powerful pieces.

Gil Bashe: Modern medicine seems to multiply silos every year. How do you see convergence breaking that pattern?

Yasushi Yamamoto: Medicine has become hyper-specialized. We have gastroenterologists who only look at the upper esophagus or the colon, cardiologists in electrophysiology, and neurologists focused on one nerve pathway. They perfect an art, but they have blinders. Convergence is breaking down those walls.

Gil Bashe: Inviting violinists and AI ethicists to the same podium can feel radical. How did people react when you pitched this mix?

Yasushi Yamamoto: People would never believe me if I hadn’t done serious work in the previous decade. Thanks to that track record, we built trust. Gathering in Okinawa sounded out of context for many professionals, but it wasn’t curiosity but trust that made them come.

Gil Bashe: Every July, you disappear into Kyoto’s 1,200-year-old Gion festival to play the traditional Japanese flute. What does a month of music teach a CEO?

Yasushi Yamamoto: Back home, I’m participating and serving. When I set up my company, I realized it would never be greater than this festival. The experience makes me humble. I received a baton from previous generations and must pass it on to the next. After that month, I ask, ‘Two generations later, how will young people judge the work I’m doing now?’

Gil Bashe: You’ve spoken of building on three “wheels”: science, art, and philosophy. Where is Corundum on that journey?

Yasushi Yamamoto: We started in hardcore science and investment, then gradually expanded to art—like Leonardo da Vinci, artist and scientist in one person. In the coming three to five years, I will put the vehicle of philosophy on top. Combining great minds and spirit, we can create something AI alone cannot deliver.

Gil Bashe: What tangible outcomes do you want from Converge?

Yasushi Yamamoto: First, I want to support OIST, an institution I love. We held the first event there; followed by South by Southwest London. I want more gatherings in multiple locations, bringing talented people with good hearts.

Gil Bashe: You’ve set up subsidiaries for neuroscience, virtual mixed human-data AI, and the microbiome. Why those intersections?

Yasushi Yamamoto: Think of the gut–brain axis. Discovery comes from interaction: AI power, system biology, and the microbiome. Add the element of art to inspire other curious, intelligent people, and the community expands.

Gil Bashe: Food as medicine used to be folk wisdom; you’re turning it into data science. How?

Yasushi Yamamoto: We invested in a project from the Weizmann Institute—the deepest phenotype cohort, hundreds of people over 20 years with genes, metabolites, behavior, nutrition. We link ancient wisdom to ultra-modern science by layering AI on that dataset. We are converging the past, the future, and current ways of life.

Gil Bashe: Philosophy sounds noble, but ventures need cash. How do you square capital with conscience?

Yasushi Yamamoto: I strongly believe in setting vision on a solid philosophical idea, but also in the power of capital. Our job is to propose a hypothesis, bring capital, deploy people, and prove the hypothesis with action. So, we’re raising our next venture fund while creating the Corundum Convergence Institute, a U.S. 501(c)(3), as an alternative financing model to advance science.

CLOSING THOUGHTS

Yamamoto-san reframes the entrepreneur’s impossible triangle—mission, money, and meaning—into an orchestral score. Science provides the bass line, art supplies melody, philosophy sets tempo, and well-deployed capital funds the concert hall. As Converge expands from Okinawa to London and beyond, its founder is betting that harmony, not hierarchy, will unlock the next era of precision health.

The takeaway is disarmingly simple for the rest of us: when great minds tune their instruments to work in harmony, the walls separating our disciplines start to fall—and patients everywhere will hear the music of life-sustaining innovation.

According to Gil Granot Mayer, Executive Vice President, Technology Development & Innovation at OIST:

“In just two days, we managed to connect people from different disciplines and geographies, immersing them in the OIST spirit and Okinawa’s culture. From understanding the value of the long tail to different approaches to improving life through the Human Phenotype Project, or the understanding of a new aging mechanism associated with cell membrane damage. I hope that these new connections and cutting-edge talks will spark new collaborations and great results.”

The post Blending Renaissance Thinking and Collaborative Power to Address Global Health Challenges appeared first on Medika Life.

The FemTech Foundation—and Fault Lines

In 2015, fewer than 300 ventures focused on women’s health existed. That number has tripled to 942, according to the Galen Growth HealthTech Alpha™ platform. These ventures now span the female health continuum—gynecology, menopause, oncology, cardiovascular disease, mental health and beyond.

Yet the investment tide has not fully turned in FemTech’s favor. While partnerships have risen 15.3-fold during the past decade, capital deployment has grown only 1.4 times. Compare that to the 2.6x expansion of digital health investments. In 2024, FemTech secured $2.2 billion in funding, a sliver of the $26 billion digital-health pie.

This disparity isn’t due to a lack of innovation—quite the opposite. The problem is systemic: funding gaps, policy voids, and clinical blind spots that overlook the $360 billion “ghost market” of women’s health. That phrase— “ghost market”—is the report’s haunting term for the opportunities left untouched by current investors and providers alike.

From Fertility to Full Spectrum

One of the report’s most critical takeaways is how much the FemTech category is maturing. Fertility tracking and pregnancy apps put the field on the map. But FemTech today is far more.  It recognizes the vast need for medicine to engage with women’s unique health needs, long unaddressed.

The Galen Growth data shows that while gynecology and oncology account for more than half of all FemTech ventures, menopause, chronic pain, autoimmune conditions, cardiovascular disease and mental health are surging into the investment and innovation spotlight. These are not “niche” categories—they represent common, often underdiagnosed or misdiagnosed conditions that disproportionately affect women and impair their quality of life.

This expansion reflects a growing recognition that women’s health is not a subset—it’s a central pillar of public health. As de Salaberry writes in a soon-to-appear Health Tech World byline: “To be transformative, FemTech must address the entirety of the women’s health continuum, including those therapeutic areas that are not traditionally branded as female-specific but affect women in distinct ways.”

Twice the Clinical Evidence—But Still Under Scrutiny

Perhaps the report’s most sobering—and telling—data point is that FemTech ventures generate nearly twice the volume of clinical trials, peer-reviewed research, and regulatory filings as their digital health peers. Twice. That’s not due to past scientific rigor; these companies are held to a higher standard. Founders and advocates must go the extra mile to validate the clinical value of their solutions.

Despite this, systemic barriers remain. The report shows 71 percent of early-stage FemTech ventures struggle to raise a Series A round. Funding the “middle”—those post-seed but pre-scaleup companies—is an urgent priority. Without it, too many promising solutions will stall before reaching the women who need them.

Let’s be clear: this isn’t just about meeting investor milestones. It’s about delivering equity in care. Cardiovascular disease is the leading cause of death among women, yet it remains underrepresented in FemTech portfolios. Alzheimer’s and autoimmune conditions disproportionately affect women, yet receive comparatively little innovation focus.

Those are not oversight gaps. They are deep, systemic failures – disparities in our health innovation system.

From Direct-to-Consumer to Deep Health Integration

Another significant signal of maturity is the shift away from pure direct-to-consumer (DTC) models. In 2024, 42 percent of FemTech partnerships involved health systems, up from just 10 percent in 2020. That’s a tectonic shift from point solutions to systemic integration.

As de Salaberry puts it, “DTC strategies alone cannot reach underserved populations or secure the reimbursement pathways necessary for scale.” Systemic integration—through payers, providers, and public institutions—is essential for sustainability and access. FemTech must live where care happens, not just on consumers’ cell phones.

Regionally, the picture is just as telling, with Europe leading in clinical rigor, with 50 percent of FemTech ventures demonstrating proven clinical strength. North America leads in funding ($1.3B), while Asia-Pacific remains a hub of AI-driven diagnostics, even amid a dip in capital investment. These trends point to what’s next: a future driven by localization, clinical excellence and technology convergence.

Forces Shaping the Future of FemTech

The report outlines five key factors shaping the FemTech evolution during the next five years. They’re worth noting for anyone investing, innovating or advocating for equitable care with an eye toward return on investment:

• Redefining the Scope: FemTech must look beyond reproductive health to address chronic diseases, aging, and behavioral health.
• Breaking the DTC Mold: Success will be defined by integrated partnerships with employers, insurers, and health systems.
• Balancing Rigor and Agility: Regulatory requirements must support innovation without stifling it.
• Funding the Growth Gap: Series A and B support is critical to help early innovators scale.
• Smart Consolidation: M&A isn’t just about exits—it’s about building category leaders with breadth and credibility.

Infrastructure, Not Hype

The key here is infrastructure. FemTech is not a trend—it’s the scaffolding of women’s health innovation. Investors need to hear that message and invest to make this population health category viable.

With nearly half the global workforce made up of women, the ROI on women’s health is not just moral—it’s macroeconomic. The health ecosystem can no longer afford to treat women’s health as an edge case. It is, in fact, the core of population health.

FemTech’s next chapter will be shaped by evidence, equity and integration. It must also be underpinned by trust from payers, providers, and patients. That trust is earned through data, outcomes and the bold assertion that women’s health is health, full stop. This Galen Growth Report goes a long way to demonstrating the positive outcomes when innovation and investment converge.

As Julien de Salaberry wisely states: “The next generation of Femtech isn’t about visibility—it’s about value, integration, and health systems impact.” That’s not just a forecast—it’s a framework for what’s next.

[Editor’s Note: For a deeper dive into the Galen Growth FemTech 2025 report, visit galengrowth.com. The full report and press release, are available now.]

The post Galen Growth FemTech 2.0 Report: Elevating Women’s Health from Niche to Necessity appeared first on Medika Life.

But the most profound insights sometimes come in the quiet moments between treatments.

I see a lot of overworked patients.

And now, neuroscience confirms what many of us have long suspected:

Overwork doesn’t just wear us down — it reshapes who we are, starting with the brain.

A recent study has illuminated something startling and validating:

The Study That Turned Heads

A groundbreaking study published in Occupational and Environmental Medicine analyzed MRI scans of 110 healthcare workers.

It found something startling:

Compared to those with standard hours, those clocking more than 52 hours a week showed structural changes in 17 brain regions.

These regions govern critical functions like decision-making, memory, attention, emotional regulation, and planning.

Jonny Gifford of the Institute for Employment Studies called the study “powerful new evidence,” explaining that these changes may explain why long hours erode judgment and resilience.

Yes, the sample was small — and limited to South Korean healthcare workers — but MRI-based neuroimaging gives it scientific weight.

Here’s where the changes show up — and why they matter.

What Does This Mean?

The affected brain areas include:

• Middle Frontal Gyrus: Working memory and attention (think: forgetting why you opened a tab).
• Insula: Emotional regulation and empathy (that short fuse? It’s not just you).
• Superior Temporal Gyrus: Processing sound and language (why everything feels “too loud” after a long day).

These changes suggest chronic overwork can reduce emotional stability, increase anxiety, and strain our closest relationships.

Frank Pega of the World Health Organization put it plainly: “The brain doesn’t just get tired. It changes.”

His 2021 WHO-ILO study estimated that long working hours contribute to 745,000 deaths annually, making them the world’s leading occupational risk factor.

Some brain areas may enlarge under stress, but growth isn’t always resilience.

Sometimes it’s your brain shouting for help.

The Brain’s Attempt to Adapt

These changes aren’t just damage — they might be neuroadaptation, the brain’s desperate attempt to cope.

But that adaptation comes at a cost.

• Emotional dysregulation.
• Cognitive fatigue.
• Burnout.

Can the Brain Bounce Back?

Are these brain changes permanent?

Maybe not.

Study coauthor Dr. Joon Yul Choi believes they may be “at least in part, reversible” — if we remove the stressors.

Your brain can heal.

But only if you give it time, space, and support.

In other words, your brain may be able to heal—but only if you give it time, space, and support.

Takeaway Checklist

If you’re working long hours, protect your brain by:

• Prioritizing at least 7 hours of sleep
• Scheduling brief recovery breaks every few hours
• Moving your body daily — even a walk counts
• Stress Management: Techniques like mindfulness can help reduce chronic stress. Consider calming rituals such as music, breathwork, prayer, or meditation.
• Talking to someone if you’re nearing the edge — don’t go it alone.

These habits don’t just feel good.

They can rebuild brain function, one small practice at a time.

And remember: this isn’t just your job.

Employers and institutions have a responsibility, too.

Burnout prevention is not a solo act.

A Personal Reflection

I’ve seen what overwork does to patients, colleagues, and myself in my practice.

The silent erosion of well-being.

The missed birthdays.

The passion that dims — slowly, then all at once.

If you’re feeling it, too, you’re not alone. You’re not imagining it.

Science is finally catching up to what many of us have long suspected.

I’ve seen it in others.

I’ve felt it in myself.

This study doesn’t just present data — it maps the quiet cost of overwork.

One brain. One story at a time.

Final Thoughts

Overwork isn’t a badge of honor.

It’s a health hazard.

“Even resilience has a tipping point. The brain can adapt — but sometimes, it cracks before it bends.” — Michael Hunter, MD.

As we chase excellence, remember that sustainability is the real superpower.

Michael Hunter, MD, is a radiation oncologist and writer exploring the intersection of medicine, humanity, and science.

If this resonated with you, you might also appreciate:

👉 10 Tiny Habits That Make You Healthier, Calmer, and Harder to Kill

It’s about what my patients near the end still wanted the world to know.

The post Overwork Is Rewiring Your Brain. Here’s What Neuroscience Wants You to Know appeared first on Medika Life.

The lead content of surface enamel at that time was determined to be high. A number of widely used dentifrices were tested for lead since it was suspected that they could be a source of this element. Every single sample tested positive for lead.

Toothpaste samples taken from certain brands showed high levels of lead in the areas immediately surrounding the product container’s walls. When squeezed from nearly empty tubes, the paste contained substantial levels of lead in these tests. These findings left little doubt that these products contained a neurotoxin that could cause harm if ingested. How many years ago was that? Yes, that was 45 years ago, and we have continued to use products that may not be as safe as they should be. But what’s the specific problem, and shouldn’t we have been protected by the agencies given that charge?

Children and Lead Exposure

There are several well-documented negative impacts of lead exposure on children’s health, including:

Brain and neurological system injury
Decreased development
Issues with learning and conduct disorders
Speech and hearing impairments

Resulting in:

Reduced intelligence of a lifelong nature
Minimal capacity for sustained attention
Academic underachievement

In children, we need to be especially concerned, as this is where the most damage can occur, and the consequences can be lifelong. Lead is harmful to children because it enters the bloodstream rapidly. Once in the bloodstream, lead is transported to the brain, bones, and every part of a child’s body. It is insidious and may not be detected immediately except when specific blood tests are performed. The question here, of course, is whether or not lead is suspected to be the culprit, and testing is ordered.

A child’s blood lead level will increase if they ingest lead. However, blood lead levels decline over time when a child’s exposure to lead ends. However, despite decreasing levels of lead, not all lead will be eliminated, and this is where the damage lies.

Kidney, perspiration, and feces are excreted by the body as a portion of the lead. Bones are another repository for lead. Lead levels in bones can decline over decades. But there’s more here than we would suspect, and we would be lulled into a false sense of security that the body has a natural ability to read itself of lead. The story is more complex than that.

Due to its ability to penetrate and remain in the body, lead is extremely harmful to children’s health. Lead can enter the blood circulation and even reach the brain when a kid breathes lead dust or consumes lead particles. Remember the toothpaste that we mentioned earlier? Lead, alarmingly, can lodge in bones and soft tissues, where it can stay for decades, unlike many poisons that the body removes.

One reason lead is so harmful is that it resembles calcium and iron, two essential minerals necessary for a growing body. Lead, when ingested, mimics these essential nutrients and fools cells into utilizing them instead. This change disrupts the brain’s normal development and functioning.

Like insulation, the protective myelin layer around nerve cells is likewise damaged by lead. Damage to this coating prevents the normal transmission of nerve signals throughout the brain. Physical and mental development, as well as learning and processing information, are all impacted by this harm. It is crucial to limit lead exposure in youngsters because the consequences can be long-lasting and happen at very low exposure levels.

Toothpaste Current Research

After all these years, researchers decided to revisit the exploration of currently available toothpastes and other potential sources of metal contamination. The results are anything but heartening and have raised new concerns for even the most well-known brands of toothpaste.

Many of the popular brands were included in a 2025 research project, and a chart is available here. In fact, you can find information on multiple products and their safety regarding contamination by lead or other materials here. It’s not only toothpaste that we need to be concerned about because we’ve recently been made aware of contaminants, such as metals, in baby food.

In the area of toothpaste, especially for children, 51 Brands were tested and, unfortunately, even those that were supposed to be “green” had issues with contamination. Lead was present in approximately 90% of toothpastes, arsenic in 65%, mercury in slightly less than half, and cadmium in one-third. Many brands have some harmful substances. Many popular brands were found to contain harmful substances, including Crest, Sensodyne, Tom’s of Maine, Dr. Bronner’s, and others.

In their defense, several corporations have pointed out that lead is ubiquitous in nature and thus impossible to eliminate. Currently, the federal Baby Food Safety Act of 2024 is stuck in Congress, which would limit lead levels in children’s food to 10 parts per billion. The lead limit in infant food in California is six parts per billion; however, this does not apply to toothpaste. The majority of toothpastes surpassed those levels.

You can find arsenic in nature just about everywhere: rocks, dirt, water, air, and even some living things. Organic chemicals, including those found in seafood (such as fish and shellfish), are one possible form they can take. However, when we detect unacceptable levels of any heavy metal, such as lead, in a product intended for oral use or ingestion, it is mandatory that we take every possible step to eliminate it. To do less is unconscionable and damaging to children and adults.

As always, it is wise to inform yourself about all the foods and materials that you will either ingest or apply to your body. This research would not have seemed necessary, except that almost 50 years ago, lead was found in toothpaste. Now that we have the information, we can act intelligently with it and protect ourselves and our children.

The post STOP! Brushing Your Teeth May Expose You to Deadly Neurotoxins appeared first on Medika Life.

For the more than 37 million Americans who suffer from migraines, the FDA authorization of Click Therapeutics’ CT-132—the first prescription digital therapeutic for the preventive treatment of episodic migraine—is more than a headline. It offers the potential for expanded access, improved quality of life, and the legitimization of digital medicine as a cornerstone of care.

Rewriting the Migraine Narrative

For people living with episodic migraine—those experiencing up to 14 migraine days a month—prevention is critical. Migraine is far more than “just a headache.” It is a neurological disease that can be disabling, impacting work, relationships, and emotional well-being.

According to the American Migraine Foundation, almost 90 percent of people with migraines are unable to work or function normally during an attack. What’s more, only about 12 percent of those with migraines receive preventive treatment—a treatment gap due to side effects, fear, access barriers, or lack of awareness.

“This is where CT-132 emerges as a potential game-changer,” said Click Therapeutics Founder and CEO David Klein in an exclusive comment to Medika Life.  “We’re entering a new era of migraine care—where doctors can harness the power of both proven medicines and clinically validated digital therapeutics to meet patients’ urgent needs.”

Data That Delivers

Until recently, the FDA approved most digital health approaches under the device 510K pathway with limited clinical data.  FDA marketing authorization for CT-132 was supported by biopharma-like data from the pivotal ReMMi-D randomized controlled trial, in which CT-132 met its primary endpoint by significantly reducing monthly migraine days on top of background pharmacotherapy,

In the bridging study, ReMMiD-C, CT-132 showed similar performance in patients on prescription calcitonin gene-related peptide (CGRP) inhibitors such as Aimovig (erenumab), Ajovy (fremanezumab), Emgality (galcanezumab), Vyepti (eptinezumab), Ubrelvy (ubrogepant), Nurtec ODT (rimegepant), and Qulipta (atogepant).  CT-132 is an adjunctive treatment to medication, giving it broad potential use.

CT-132, delivered via a mobile app, achieved statistically and clinically meaningful results in the ReMMi-D pivotal trial. Participants who used the digital therapeutic reported a mean reduction of 3.04 monthly migraine days, compared to just 0.9 days in the sham group (p=0.005). That means real days—at work, with family, outside in the sun—returned to people’s lives.

In a condition where every single migraine-free day matters, the ability to deliver those gains without pharmacological side effects through a smartphone app democratizes access to care. It opens the door to new options, particularly for those who cannot tolerate or access traditional therapies.

“This marks a significant milestone for the more than 37 million adults in the US who live with migraine,” said Shaheen Lakhan, MD, PhD, FAAN, Chief Medical Officer of Click Therapeutics. “CT-132 offers eligible patients a new path to reducing the burden caused by migraine—one they can access anywhere via an evidence-based mobile application on their smartphone.”

Digital Care, Doctor-Led

Importantly, CT-132 does not sideline clinicians—it includes them as front-and-center leaders in care delivery. As a prescription-only digital therapeutic, CT-132 is designed to be used under the guidance of a health provider, adding a new clinical approach to physician-directed personalized care. It enhances—not replaces—traditional physician-patient relationships by enabling clinically validated, behavior-based treatment delivered consistently between visits.

Neurologists and primary care providers who manage migraines now have an evidence-based, non-drug adjustive approach to care, especially to patients who have tried multiple therapies and continue to have breakthrough episodes.

Data is the Gatekeeper

The approval also signals a broader truth long-awaited in digital health: evidence is everything. As digital therapeutics gain traction, the FDA and the medical community are asking for the same rigor as traditional pharmaceuticals.

“For digital health ventures to gain the confidence of regulators, providers, and patients, clinical validation must be central,” said Julien de Salaberry, CEO of Galen Growth. “This approval is a reminder that digital therapeutics can meet gold-standard evidence expectations—and that’s how they earn a place in modern medicine.”

[See Medika Life special report: Consumer HealthTech: A Data-Driven Evolution in Health Engagement]

According to Galen Growth analytics, only 24 percent of digital health companies globally have demonstrated clinical strength through trials or peer-reviewed publications. CT-132 stands out and sets the bar. Generating clinical evidence in digital health has become a marker for success. Galien Growth recently published its landmark analysis of digital health and consumer use, which includes the importance of data for product and category progress.

A Future Forward

The approval of CT-132 reflects a movement in medicine, reimagining how we define treatment, access, and wellness. It’s a reminder that innovation is not just about what is possible, more importantly, what is proven. As more digital therapeutics enter the pipeline, the CT-132 journey offers a case study of what it takes to cross the threshold from hope to health reality.

This approval to market brings something invaluable to people with migraines: urgency. The ability to be treated anywhere, on their terms, using science-backed interventions, gives people not just fewer migraines but more voice in their care.

This is not just a regulatory milestone. It’s a human one.

[This article is not sponsored or requested by any company. The author has been covering digital health since 1995 and seeks to highlight sector trends. He maintains editorial independence.]

The post A Digital Turning Point in Migraine Care: CT-132 FDA Approval to Market is a Win for Patients and Proof that Clinical Evidence Matters appeared first on Medika Life.

What’s more, exercise is just not for your muscles and your strength. I’ve written on why muscles are involved in mood and you can go to this article to refresh your memory or read it if you haven’t already.

What recent research benefits those over 70? Undoubtedly, we have a great deal more in terms of input in our muscle maintenance than anyone thought when they considered people over 70. The newest research refutes that myth, providing new insights and amazing changes for this group.

But there are specific periods in our lives when certain changes will begin, and with each phase, there will be almost undiscernible changes. However, there are indications that those above 70, who are at greatest risk for instability, balance, problems, muscle weakness, and even bone fractures, require our attention. Previously, adequate work was not directed at the potential maintenance and retrieval of muscle strength in this group, and that is where new, exciting research is coming to the fore.

What Are the Groups?

Sarcopenia is the medical term for muscle loss, and it is a normal aging process that affects all humans, although the rate of onset and the severity of the condition is different among individuals. This slowdown in muscle mass, strength, and function has implications for the quality of life and dependence of the elderly. Muscle loss occurs at different ages and we need to pay attention to enable people to prevent or at least remediate this to some extent.

20s-30s Age Group

In the young adulthood (20s to 30s) age group, muscle mass is at its peak. This age group is likely to have the best muscle strength and function as most people. The body is well equipped to build up and preserve muscle tissue as long as the muscle is used and fed properly. However, even at this young stage, people with sedentary jobs may already experience some muscle atrophy that does not manifest itself clinically. It sets the stage for future deterioration, so appropriate physical activity and diet during these years are a sound investment into future muscle health.

40s Group

Beginning in the 40s, the person begins to show some changes as mentioned above. The literature reviews indicate that muscle mass starts to decline at about 0.5–1% every year after age 30 and the rate increases a little in the 40s. It is also the time when strength reduction is first noticed especially in muscle fibers which control power and speed.

The quadriceps, hamstrings, and calf muscles may start to weaken, especially in people with low levels of physical activity. Most people in this age bracket feel the fatigue and reduced physical endurance when engaging in physical activities.

50s Group

More specific features of muscle atrophy can be observed in the 50s. The rate of loss is higher, currently ranging between 1–2% every year. At this time, the hormonal changes worsen the muscle regeneration. To women menopause reduces the level of estrogen that accelerates muscle loss. Men also have low levels of testosterone that also worsen the muscle tissue.

The abdominal muscles and the lower back muscles, which are the stabilizers, also weaken a lot. Upper body strength, especially in the chest, shoulders, and arms, decreases at a higher rate than before.

60 Group

In the 60s, the loss of muscle is higher and the following rates are observed: 2–3% per year. The consequences of the changes are seen in the everyday life and the person needs help in performing certain actions. The muscles of the lower limb that include the quadriceps, hamstrings and gluteal muscles also weaken greatly.

Many people in this age group will report having problems with stairs, getting up from a chair, or walking for long distances. The hand grip strength is reduced which in turn affects the fine motor skills and the ability to handle objects. The sense of balance is also affected because muscle weakness and neurological changes in proprioception occur.

Over 70 Group

Muscle loss is at its highest in adults over 70, with annual losses of 3–5% if no schedule for slowing or reversing this loss is introduced. This accelerated decline has a major effect on the quality of life and independence. This age group has distinct muscle weakness with well-defined patterns of muscle involvement that have important functional implications

The quadriceps, hamstrings and gluteal muscles are the extremity muscles that are affected in a greater degree. This weakness is manifested as:

1. Difficulty in rising from sitting position
2. Slow walking
3. High chances of falling,
4. Difficulty in climbing stairs. The ankles are also liable to weaken, and this causes the client to have difficulty with walking and increased chances of falling.

Strengthen these muscle groups by including functional exercises that may involve using body weight, resistance bands, or light weights. Of course, any exercise routine in any age group should always be planned with a certified trainer or someone in a rehabilitation facility specifically to address these needs.

Some of the exercises that can be of great help include; standing from a chair, slow walks, sitting leg raises, and ankle exercises to build strength. Exercises in water are an excellent way to work on these muscles with minimum impact on the joints.

Balance is trained very effectively by standing exercises that reduce the base of support step by step. The tandem stance is particularly effective — this is when one stands with one foot in front of the other, heel to toe, to begin with, leaning on a sturdy chair or counter. In the event that stability improves, the support can be reduced to fingertip touch, then to no support at all.

The single leg stance is another basic exercise; start by holding a chair and lift one foot slightly off the floor for 10–15 seconds and then switch to the other side. This exercise directly strengthens the stabilizing muscles around the hips and ankles that are crucial for the prevention of falls.

Weight shifting exercises are used to develop the dynamic balance. The weight shift is to stand with feet hip width apart and then slowly shift weight from one foot to the other without moving the feet. Clock reaches expand on this by visualizing standing at the centre of a clock face and reaching one foot towards different ‘hours’ whilst remaining balanced. These movements enhance proprioception, which is the sense of where the different parts of the body are in space, and this sense is often reduced as one gets older.

The good news is that even though you have lost muscle strength, there is still the ability to help your muscles, pull back some of that strength and renew your ability to move and continue an active lifestyle. As has been noted by several of the articles, water exercises seems to be one of the best, especially for anyone with arthritic conditions. And, don’t forget that exercise is intimately associated with mood.

The post Strength Beyond Years: How Exercise Redefines Aging appeared first on Medika Life.

Alzheimer’s disease is mostly marked by dementia that includes memory problems, cognitive problems, executive dysfunction, and changes in attitude and behavior. Most people with this disease also have signs of a mental disorder. Careful attention and medicine can help with these signs for a short time, but there are no specific ways to stop or cure Alzheimer’s disease.

Dementia mostly affects older people, and the rates of occurrence and prevalence rise with age. This is more common in low- and middle-income countries and places. It is putting a lot of stress on families and societies in terms of money and illness. What does this mean for you if you have someone in your family with AD?

Based on studies of twins, AD is thought to be passed down 70% of the time. Clinically diagnosed AD has found more than 70 genomic loci in people with mostly European heritage. The discovery of these new genomic loci must be taken with a grain of salt.

Let’s look at what genetic inheritance can and cannot do and what may affect it. Even if you had a gene for a specific illness, even a serious mental illness, it might never be what we call “expressed” because there are a variety of things that must coalesce to make that happen.

A cell’s gene expression code is similar to a cookbook. Essential for all bodily functions, each gene is a blueprint for the production of a particular protein. The frequency with which your genes are activated or deactivated, or expressed, depends on a number of conditions.

At birth, you have a blueprint for your genes in the form of your DNA. But environmental factors, including your diet, level of physical activity, and smoking status, can affect gene expression. You name it; it can be impacted by factors including the medications you take.

Also, your gene expression might alter with age or specific medical issues. Although your DNA cannot be changed, there are certain things that can be altered, such as your lifestyle and the environment in which you are born. You can use this to keep yourself healthy and control certain medical issues.

Stress is one of the factors that has been indicated to potentially push these genes to become evident in behaviors, but what else could do it? There are too many variables regarding what might cause it to flare up, and the problem becomes knowing you have a gene for something specific and wondering if you will ever experience it in a behavior of some type.

It is possible that more than a third of cases of dementia could be avoided. Getting kids to go to school and exercise more, keeping up with friends and family, smoking less or quitting altogether, and taking care of hearing loss, depression, diabetes, high blood pressure, and obesity could all help avoid or delay dementia. There is also some early information about other risk factors that might be able to be changed.

What Does This Mean?

It is possible that further research based on these results may help diagnose and cure diseases in the future. Those who are concerned about the possibility of AD, or who have been found to have the genes, should consider the following:

1 Stay Informed: Learn about current research and developments in Alzheimer’s disease, the genetic basis of the disease, and how this can be managed through changes in lifestyle.

2. Talk about genetic risks. If your family has a history of Alzheimer’s disease, you should see your doctor about genetic testing to assess your risk.

3. Stick to the basics when it comes to keeping fit and avoiding illness — a healthy diet, regular exercise, keeping the mind active, and the control of chronic diseases such as diabetes and hypertension.

4. Consider participating in research. It is important that more people from different backgrounds become a part of the study to help advance research and develop more personalized treatments.

5. Keep talking to your doctor. Genetic study is interesting, but the best way to handle health issues is to prevent them from happening in the first place through the help of current treatments. If there is anything that you have concerns about or what to do next, you should report it to your healthcare provider.

How Do Interventions Work?

Lifestyle: Engaging in mental exercises on a regular basis, such as solving puzzles, reading, or picking up new skills, can help build cognitive reserve and potentially postpone the start of symptoms.

Sleep: The brain is able to eliminate toxic proteins and consolidate memories when you maintain a quality sleep routine of seven to eight hours per night.

Stress management: Reduced cortisol levels, which can eventually harm brain cells, are one benefit of stress management practices like mindfulness and meditation.

Smoking and alcohol: Promoting brain health through avoiding smoking and limiting alcohol use helps to maintain adequate blood flow and reduce inflammation. Smoking acts as a stress-reduction technique because nicotine is a natural substance reducing anxiety, but the downside is cancer.

Aerobic exercise promotes neuronal and synaptic growth by increasing blood flow to the brain, which carries oxygen and nutrients. By keeping insulin sensitivity high, resistance exercise protects against cognitive loss caused by diabetes and promotes overall brain health. Physical exercise improves clearance processes, which may lower beta-amyloid plaques, a characteristic of Alzheimer’s disease. Regular moderate exercise, even for just 150 minutes a week, improves cardiovascular health, decreases inflammation, and drastically reduces the risk of Alzheimer’s disease.

Socialization: The brain’s neural connections and plasticity are both supported by the cognitive stimulation that occurs during regular social contact, which is a key component of socialization. Potentially as a result of less stress and a stronger feeling of purpose, those with strong social networks have slower rates of cognitive deterioration. One of the most effective ways to stave off cognitive loss is to participate in group activities that mix socializing with mental or physical demands. Dementia risk factors include social isolation; in fact, research suggests that those who are lonely may have twice the chance of getting Alzheimer’s as those who have strong social connections.

Diet: The anti-inflammatory features of the Mediterranean and MIND diets have been associated with a substantially reduced risk of Alzheimer’s disease. These diets are rich in leafy greens, berries, nuts, fish, and olive oil. Free radicals damage brain cells and contribute to cognitive loss; foods rich in antioxidants can neutralize these radicals.

Overall, despite any genetic inheritance, we may have more power over our cognition than we have been led to believe in the past. Regularly attending to the above points can improve our mental and physical health, as shown by research, and lead to positive outcomes.

The post Alzheimer’s New Gene Discovery May Prove Decisive in Early Diagnosis or Not. What CAN You Do? appeared first on Medika Life.

The observational study, which followed a large group of older adults, discovered this:

Individuals with cancer were less likely to develop Alzheimer’s than those without cancer.

The association appeared consistent across several common cancer types, including breast, prostate, and lung cancer.

Study Details

This study utilized a large population-based cohort analysis drawing from the UK Clinical Practice Research Datalink (CPRD), encompassing 3,021,508 individuals aged 60 and older.

Researchers collected data over 30 years (1988–2018).

Study Results

After an average follow-up of 9.3 years, individuals with cancer exhibited a one-quarter (25 percent) lower risk for dementia than the rest of the cohort.

Here are the key findings:

• Overall, cancer was associated with a lower risk of dementia.
• This association was observed regardless of whether cancer developed after database entry or was present at entry.
• When accounting for the competing risk of death, the protective effect of cancer against dementia was even more pronounced.
• Specific cancer types, including breast, prostate, lung, colorectal, and melanoma, were all individually linked to a significantly lower dementia risk (lower risk from one-third to one-fifth).

My Thoughts

The researchers are not sure why cancer may be associated with a lower Alzheimer’s disease risk.

The authors acknowledge some study limitations, including the potential underreporting of dementia.

We need more research to confirm these observational findings.

For now, here are some things we all can do to reduce our Alzheimer’s disease risk potentially:

• Eat a healthy diet.
• Get regular exercise.
• Maintain a healthy weight.
• Don’t smoke.
• Limit alcohol use.
• Get enough sleep.
• Manage stress.
• Stay socially connected.

If you have cancer, it is important to talk to your doctor about ways to reduce your risk of Alzheimer’s disease.

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